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Research Achievements

As of 2022.Mar

153

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Presentations at Scientific Conferences

51

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New Patent Applications

7

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Programs Supported by Public Funds

28

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Publications in Scientific Journals

 
 


Publications

  • [New]Generation of a human SOX10 knock-in reporter iPSC line for visualization of neural crest cell differentiation
    Teruyoshi Yamashita, Daisuke Kamiya, Nami Kawaraichi, Harufu Toyokaw, Teppei Akaboshi, Makoto Ikeya, Yayoi Toyooka
    Stem Cell Research Volume 60, April 2022, 102696

  • Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges
    Eman A.Taha, Joseph Lee, Akitsu Hotta
    Journal of Controlled Release Volume 342, February 2022, Pages 345-361

  • Generation of human GAPDH knock-in reporter iPSC lines for stable expression of tdTomato in pluripotent and differentiated culture conditions
    Daisuke Kamiya, Teruyoshi Yamashita, Teppei Akaboshi, Yoshiki Yamaguchi, Yayoi Toyooka, Makoto Ikeya
    Stem Cell Research Volume 60, April 2022, 102704

  • Assay for the peptide:N-glycanase/NGLY1 and disease-specific biomarkers for diagnosing NGLY1 deficiency
    Hiroto Hirayama, Tadashi Suzuki
    J Biochem. 2022 Feb 21;171(2):169-176. doi: 10.1093/jb/mvab127.

  • Ameliorative effect of anti-complement factor antibody on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected macaque
    Yasunori Nio
    Translational and regulatory sciences 2021 Volume 3 Issue 3 Pages 98-101

  • Orai1-STIM1 regulates increased Ca2+ mobilization, leading to contractile Duchenne muscular dystrophy phenotypes in patient-derived induced pluripotent stem cells.
    Tomoya Uchimura and Hidetoshi Sakurai
    Biomedicines 2021, 9(11), 1589; https://doi.org/10.3390/biomedicines9111589

  • A method for assaying peptide: N-glycanase/N-Glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide.
    Hiroto Hirayama, Yuriko Tachida, Junichi Seino, Tadashi Suzuki
    Glycobiology, Volume 32, Issue 2, February 2022, Pages 110–122,
    https://doi.org/10.1093/glycob/cwab115

  • Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
    Eriya Kenjo, Hiroyuki Hozumi, Yukimasa Makita, Kumiko A. Iwabuchi, Naoko Fujimoto, Satoru Matsumoto, Maya Kimura, Yuichiro Amano, Masataka Ifuku, Youichi Naoe, Naoto Inukai & Akitsu Hotta

    Nature Communications volume 12, Article number: 7101 (2021)
    Details(JP)

  • A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs
    Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, and Hidetoshi Sakurai

    Cell Rep Med. 2021 Jun 4;2(6):100298. doi: 10.1016/j.xcrm.2021.100298

  • Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase
    Yukiko Yoshida,  Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida,  Reiko Fujinawa,  Kazuhiro Iwai,  Ryuichi Tozawa,  Noriyuki Matsuda, Keiji Tanaka, and  Tadashi Suzuki

    PNAS July 6, 2021 118 (27) e2102902118; https://doi.org/10.1073/pnas.2102902118

  • Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
    Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii and Tadashi Suzuki

    Molecular Brain 14, Article number :91, 2021
    Details (JP)

  • ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
    Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, and Yoshinori Yoshida

    Nature Communications 12, Article number :3596, 2021
    Details (JP)

  • A clinically applicable and scalable method to regenerate T-cell from iPSCs for off-the-shelf T-cell immunotherapy
    Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi & Shin Kaneko
    Nature Communications 12, Article number:430, 2021
    Details(JP)
    Details(EN)

  • JF1/B6F1 Ngly1 -/- mouse as an animal model of NGLY1 deficiency
    Makoto Asahina
    Proceedings of the Japan Academy, Ser. B

  • Current status and future perspectives of HLA-edited induced pluripotent stem cells
    Keiko Koga, Bo Wang & Shin Kaneko
    Inflammation and Regeneration 40, Article number:23, 2020

  • The promise of human organoids in the digestive system
    Masaaki Funata, Yasunori Nio, Derek M. Erion, Wendy L. Thompson & Takanori Takebe
    Cell Death & Differentiation 28, 84-94 (2021)

  • Prediction of Compound Bioactivities Using Heat-Diffusion Equation
    Tadashi Hidaka, Keiko Imamura, Takeshi Hioki, Terufumi Takagi, Yoshikazu Giga, Mi-Ho Giga, Yoshiteru Nishimura, Yoshinobu Kawahara, Satoru Hayashi, Takeshi Niki, Makoto Fushimi, Haruhisa Inoue
    Patterns Volume 1, Issue 9, 11 December 2020, 100140
    Details(JP)
    Details(EN)

  • Polygenic architecture informs potential vulnerability to drug-induced liver injury
    Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori, Yasunori Nio, Paola Nicoletti, Guruprasad P. Aithal, Ann K. Daly, Paul B. Watkins, Hisashi Anayama, Yvonne Dragan, Tadahiro Shinozawa & Takanori Takebe
    Nat Medicine (2020). https://doi.org/10.1038/s41591-020-1023-0
    (Detail)JP
    (Detail)EN

  • Ngly1−/− rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems
    Makoto Asahina, Reiko Fujinawa, Sayuri Nakamura, Kotaro Yokoyama, Ryuichi Tozawa, Tadashi Suzuki
    Human Molecular Genetics, 2020 Apr https://doi.org/10.1093/hmg/ddaa059

  • Peter Gee, Mandy S.Y. Lung, Yuya Okuzaki, Noriko Sasakawa, Takahiro Iguchi, Yukimasa Makita, Hiroyuki Hozumi, Yasutomo Miura, Lucy F. Yang, Mio Iwasaki, Xiou H. Wang, Matthew A. Waller, Nanako Shirai, Yasuko O. Abe, Yoko Fujita, Kei Watanabe, Akihiro Kagita, Kumiko A. Iwabuchi, Masahiko Yasuda, Huaigeng Xu, Takeshi Noda, Jun Komano, Hidetoshi Sakurai, Naoto Inukai, Akitsu Hotta
    Nature Communications, 11,2020
    (Detail)

  • Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

  • Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice
    Taisuke Mochida, Hikaru Ueno, Noriko Tsubooka-Yamazoe, Hideyuki Hiyoshi, Ryo Ito, Hirokazu Matsumoto, Taro Toyoda
    Diabetes 2020 Apr; 69(4): 634-646.
    (Detail)

  • Identification of 2,6-Disubstituted-3Η-imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived iPSCs
    Hiroyuki Takada, Akira Kaieda, Michiko Tawada, Tomoko Nagino, Katsunori Sasa,
    Tatsuo Oikawa, Akiko Oki, Tomoya Sameshima, Kazumasa Miyamoto, Makoto Miyamoto, Yuko Kokubu, Ryuichi Tozawa, Hidetoshi Sakurai, Bunnai Saito
    Journal of Medicinal Chemistry, 2019 Oct 24;62(20):9175-9187

  • Organoid Models of Development and Disease Towards Therapy
    Yasunori Nio, Takanori Takebe
    Medical Applications of iPS Cells, Springer Nature eBOOK, 2019, 149-168

  • オルガノイド医療の可能性と課題
    Momoko Oohori, Yasunori Nio, Eri Kawakami
    実験医学 38(1): 44-49, 2020.

  • Phenotypic Drug Screening for Dysferlinopathy Using Patient‐Derived Induced Pluripotent Stem Cells
    Yuko Kokubu, Tomoko Nagino, Katsunori Sasa, Tatsuo Oikawa, Katsuya Miyake, Akiko Kume, Mikiko Fukuda, Hiromitsu Fuse, Ryuichi Tozawa, Hidetoshi Sakurai
    Stem Cells Transl Med. 2019 Jun 28. doi: 10.1002/sctm.18-0280.
    (Detail)

  • 肝オルガノイド技術を用いたiPS創薬戦略
    Eri Kawakami, Takanori Takebe
    細胞, 2019.04.01

  • Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
    Atsutaka Minagawa, Toshiaki Yoshikawa, Masaki Yasukawa, Akitsu Hotta, Mihoko Kunitomo, Shoichi Iriguchi, Maiko Takiguchi, Yoshiaki Kassai, Eri Imai, Yutaka Yasui, Yohei Kawai, Rong Zhang, Yasushi Uemura, Hiroyuki Miyoshi, Mahito Nakanishi, Akira Watanabe, Akira Hayashi, Kei Kawana, Shin Kaneko
    Cell Stem Cell, 2018, vol.23, 850-858
    (Detail)